Last updated: September 24, 2026
The Ordinary Multi-Peptide + HA Serum, better known as “Buffet,” and Medik8 Liquid Peptides are two popular peptide serums at very different price points. Both aim to soften the look of fine lines and improve firmness over time without the irritation of retinoids. The Ordinary is known for its affordability and dense peptide blend; Medik8 positions its serum as an advanced peptide complex for expression lines. Here is how they compare and who should choose which.
Quick comparison
| Feature | The Ordinary Buffet | Medik8 Liquid Peptides |
|---|---|---|
| Main ingredients | Multiple signal peptides (e.g., Matrixyl-type and Argireline-type), hyaluronic acid, amino acids | Multi-peptide complex targeting expression lines (check label) |
| Texture | Light, slightly tacky serum | Light, fluid serum |
| Typical price (30 ml) | ~$17–22 | ~$50–65 |
| Fragrance | Unscented | Check current label |
| Irritation risk | Low | Low |
| Best for | Budget-friendly, all-round anti-aging support | Targeted expression lines, premium feel |
How peptides work
Peptides are short chains of amino acids. In skincare, several types are used. Signal peptides (such as palmitoyl pentapeptide-4, a Matrixyl ingredient) are designed to encourage skin to produce more collagen. Neurotransmitter-inhibiting peptides (such as acetyl hexapeptide-8, often sold as Argireline) are marketed to relax the look of expression lines. Evidence for peptides is less extensive than for retinoids or vitamin C, and results are generally modest and gradual, but many are well tolerated.
Density vs targeting
Buffet includes a broad mix of peptides, amino acids and hyaluronic acid in one formula. Medik8 Liquid Peptides focuses on a complex aimed at expression lines, with a more elegant texture. More peptides in a formula does not automatically mean better results; concentration, stability and formulation also matter.
Which suits your skin?
| Situation | Better pick | Why |
|---|---|---|
| Budget-focused | Buffet | Much lower cost |
| Forehead and crow’s-feet lines | Medik8 | Expression line focus |
| Sensitive skin that can’t use retinoids | Either | Peptides are generally gentle |
| Wants one serum for hydration plus peptides | Buffet | Added hyaluronic acid and amino acids |
| Prefers elegant textures | Medik8 | Smoother feel |
| Pregnant, avoiding retinoids | Either, with medical advice | Peptides are commonly chosen alternatives |
How to use peptide serums
Apply after cleansing and toner, before heavier serums and moisturizer. Use morning, night or both. Peptides pair well with most skincare, including retinoids, niacinamide and hyaluronic acid.
Pairing with other actives
- Retinoids: a strong combination; apply peptides first or on alternate nights.
- Vitamin C (L-ascorbic acid): some prefer to separate low-pH vitamin C from peptides to protect stability; use vitamin C in the morning and peptides at night.
- Exfoliating acids: use on different nights to avoid peptide breakdown and irritation.
- Copper peptides: avoid layering with strong acids or vitamin C at the same time.
What results to expect
Peptides work gradually. Expect skin to feel smoother and look more hydrated within a few weeks, with any improvement in the look of fine lines typically taking 8–12 weeks. Peptides will not replicate the effect of neurotoxin injections, whatever the marketing suggests.
Realistic comparison with retinoids
If your skin tolerates retinoids, they generally deliver more visible results for fine lines and texture. Peptides are best as a complement, or as an alternative for people who cannot use retinoids.
Value
At about a third of the price, Buffet offers strong value if you want peptides in your routine. Medik8 costs more but offers a more targeted formula and elegant feel. Both 30 ml bottles last roughly 6–10 weeks with once- or twice-daily use, so over a year Buffet costs roughly $100–150 versus $300–450 for Medik8.
How to judge whether it is working
Take close-up photos of your forehead and eye area in consistent daylight before starting, then again at weeks 6 and 12. Peptide changes are subtle and easy to miss day to day. If you see no difference after three months of consistent use, the more expensive serum is unlikely to change the outcome much; a retinoid, if tolerated, is the next evidence-based step.
Who should avoid them
Peptide serums are generally well tolerated, but anyone with a known sensitivity to specific peptides or formula ingredients should check labels. People with active dermatitis should pause new products until skin settles. Stop use if you notice itching, rash or persistent redness. Anyone expecting results comparable to medical procedures should consult a dermatologist about appropriate treatments.
FAQ
Is Buffet a dupe for Medik8 Liquid Peptides?
Not exactly. Both are multi-peptide serums, but their peptide choices and concentrations differ. Buffet is a budget alternative rather than an exact match.
Can I use peptides and retinol together?
Yes. Many people apply a peptide serum first, then retinol, or alternate nights. This combination supports smoother-looking skin with good tolerance.
Bottom line
Choose The Ordinary Buffet if you want an affordable, broad-spectrum peptide and hydration serum that pairs easily with retinoids. Choose Medik8 Liquid Peptides if you want a premium, expression-line-focused serum with an elegant texture and do not mind paying more. Keep expectations realistic: peptides offer gradual, modest improvements.
